The Isle of Man Met Office has predicted winds could reach gale force nine overnight reaching 50mph (80km/h).
The Steam Packet Company has cancelled the evening sailing between Douglas and Heysham at 19:45 (GMT) on Tuesday.
A spokesman said three services between Douglas and Heysham, scheduled for 10 December, have also been cancelled because of the weather.
They include the 02:15 GMT from Heysham to Douglas, the 08:45 return journey to Heysham and the 14:15 sailing from the Isle of Man.
A decision about the 19:45 service between Douglas and Heysham on Wednesday is expected to be made a few hours before the scheduled sailing time.
Passengers are advised to contact the Steam Packet Company for more information.